Rhodes S E V, Killcross A S
School of Psychology, Cardiff University, Cardiff CF10 3AT, UK.
Eur J Neurosci. 2007 Apr;25(8):2498-503. doi: 10.1111/j.1460-9568.2007.05486.x.
It is well established that extinction is highly context dependent, and several behavioural phenomena associated with the expression of extinction (spontaneous recovery, reinstatement and renewal) have been described as resulting from this context dependency. It has previously been shown that lesions of the infralimbic (IL) region of the medial prefrontal cortex result in increased levels of spontaneous recovery and reinstatement of an extinguished appetitive Pavlovian conditioned response. The current study shows that lesions of the IL cortex also result in increased renewal of a conditioned response when tested in the acquisition context. Thirteen IL-lesioned and 14 sham-lesioned rats were trained on an appetitive Pavlovian task in one context (Context A) followed by extinction in a different context (Context B); animals were then tested for renewal of responding in both Context A and B. Both groups demonstrated similarly low levels of responding when tested in the extinction context (B), and greater responding (i.e. renewal) when tested in the acquisition context (A). Further, the level of response renewal was greater in IL-lesioned animals. The results are discussed in relation to the possible role of the IL cortex in contextual control of extinction.
众所周知，消退高度依赖于情境，与消退表达相关的几种行为现象（自发恢复、重新激发和恢复）已被描述为由这种情境依赖性导致。先前的研究表明，内侧前额叶皮质的下缘（IL）区域受损会导致自发恢复水平增加以及消退的食欲性巴甫洛夫条件反应重新激发。当前的研究表明，在习得情境中进行测试时，IL皮质受损也会导致条件反应的恢复增加。13只IL损伤大鼠和14只假损伤大鼠在一种情境（情境A）中接受食欲性巴甫洛夫任务训练，随后在不同情境（情境B）中进行消退训练；然后对动物在情境A和B中反应的恢复情况进行测试。两组在消退情境（B）中测试时表现出相似的低反应水平，而在习得情境（A）中测试时反应更大（即恢复）。此外，IL损伤动物的反应恢复水平更高。结合IL皮质在消退情境控制中的可能作用对结果进行了讨论。
