Likitnukul S, Prapphal N, Limudomporn S, Chumdermpadetsuk S, Nunthapisud P
Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Thailand.
J Med Assoc Thai. 1991 Jun;74(6):340-3.
A case of serious suppurative disease caused by GABHS in a previously well 2-month-old Thai female presenting with clinical features of sepsis and right pleural effusion was reported. Treatment was initially with cloxacillin and a right side intercostal drainage. When subsequent cultures of blood and pleural fluid grew GABHS; intravenous penicillin was substituted. She made an uneventful recovery. Typing of the GABHS revealed non typable T-antigen and M-protein 11 GABHS, although very sensitive to penicillin, can cause severe and rapidly progressive disease in a very young infant. This is the first case of GABHS type M11 causing pleural effusion and sepsis in an infant ever reported in Thailand. Epidemiologic study might be indicated if an epidemic should occur.
据报道，一名2个月大的泰国健康女婴因A群链球菌（GABHS）感染引发严重化脓性疾病，出现败血症和右侧胸腔积液的临床症状。最初使用氯唑西林治疗并进行右侧肋间引流。随后血液和胸腔积液培养发现GABHS生长，遂改用静脉注射青霉素。她顺利康复。对该GABHS进行分型显示为不可分型的T抗原和M蛋白11型。GABHS虽然对青霉素非常敏感，但可在非常年幼的婴儿中引起严重且进展迅速的疾病。这是泰国首次报道M11型GABHS导致婴儿胸腔积液和败血症的病例。如果发生疫情，可能需要进行流行病学研究。
