Bootland L H, Hill W G, Sinnett-Smith P A
Institute of Cell, Animal and Population Biology, University of Edinburgh.
J Endocrinol. 1991 Oct;131(1):19-24. doi: 10.1677/joe.0.1310019.
The effects of exogenous GH on growth and body composition were investigated in lines of mice selected for high or low body weight (P-lines) or high or low body fat (F-lines). Mice from all lines were given daily injections of recombinant bovine GH or a placebo for 21 days from 4 weeks old. They were killed and various organ weights measured. There was no consistent effect of GH on organ weights. In all lines of mice the rate of weight gain and final weight increased in response to GH. In both lines selected for body fat, GH treatment decreased fat content. The low body weight mice also became less fat, but in the high body weight mice GH treatment increased fat percentage. The results indicate that the differences in growth rate and body composition observed in these lines are not due to differences in responsiveness to GH.
在为高体重或低体重（P系）或高体脂或低体脂（F系）选育的小鼠品系中，研究了外源性生长激素（GH）对生长和身体组成的影响。从4周龄开始，给所有品系的小鼠每日注射重组牛生长激素或安慰剂，持续21天。然后将它们处死并测量各种器官的重量。生长激素对器官重量没有一致的影响。在所有品系的小鼠中，体重增加率和最终体重均因生长激素而增加。在两个为体脂选育的品系中，生长激素治疗降低了脂肪含量。低体重小鼠的脂肪也减少了，但在高体重小鼠中，生长激素治疗增加了脂肪百分比。结果表明，在这些品系中观察到的生长速率和身体组成的差异并非由于对生长激素反应性的差异。
