Akerman G, Mignon A, Tsatsaris V, Jacqmin S, Cabrol D, Goffinet F
Maternité Port-Royal, hôpital Cochin, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
J Gynecol Obstet Biol Reprod (Paris). 2007 Jun;36(4):389-92. doi: 10.1016/j.jgyn.2007.03.004. Epub 2007 Apr 18.
Calcium channel blockers of the dihydropyridin's family have been associated with the onset of an acute pulmonary edema when they are used as a treatment of preterm labor. We report here four cases of pulmonary edema in pregnant women treated with nicardipine (Loxen) for preterm labor. The physiopathology of pulmonary edema, the pharmacology of calcium channel blockers of dihydropyridin's family and the detailed analysis of our cases and those of the literature make us discuss of the role of these agents and associated population and risk factors in such complication.
二氢吡啶类钙通道阻滞剂在用于治疗早产时，与急性肺水肿的发生有关。我们在此报告4例使用尼卡地平（洛心）治疗早产的孕妇发生肺水肿的病例。肺水肿的病理生理学、二氢吡啶类钙通道阻滞剂的药理学以及对我们的病例和文献病例的详细分析，促使我们讨论这些药物以及相关人群和危险因素在这种并发症中的作用。
