Yazdanpanah Mojgan, Aulchenko Yuri S, Hofman Albert, Janssen Joop A M J L, Sayed-Tabatabaei Fakhredin A, van Schaik Ron H N, Klungel Olaf H, Stricker Bruno H C H, Pols Huibert A P, Witteman Jacqueline C M, Lamberts Steven W J, Oostra Ben A, van Duijn Cornelia M
Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
Diabetes. 2007 Jul;56(7):1905-12. doi: 10.2337/db06-1127. Epub 2007 Apr 19.
Most studies on the genetic determinants of blood pressure and vascular complications of type 2 diabetes have focused on the effects of single genes. These studies often have yielded conflicting results. Therefore, we examined the combined effects of three renin-angiotensin system (RAS) genes and three salt sensitivity genes in relation to blood pressure and atherosclerosis in the total population and type 2 diabetic patients. The study was a part of the Rotterdam Study, a population-based cohort study. We have genotyped three RAS gene polymorphisms and three salt sensitivity gene polymorphisms. Diabetic patients with three risk genotypes of the RAS genes had a 6.9 mmHg higher systolic blood pressure (P for trend = 0.04) and a 6.0 mmHg higher pulse pressure (P for trend = 0.03) than those who did not carry any risk genotypes. Diabetic patients with three risk genotypes of the salt sensitivity genes had a 9.0 mmHg higher systolic blood pressure (P = 0.19) and a 13.1 mmHg higher pulse pressure (P = 0.02). Diabetic patients who carried three risk genotypes for the RAS genes had a higher mean intima-media thickness than those with two risk genotypes (mean difference 0.04 mm, P = 0.02). We found that among type 2 diabetic patients, mean systolic blood pressure, pulse pressure, and risk of hypertension increased with the number of risk genotypes for the RAS genes and the salt sensitivity genes.
大多数关于2型糖尿病血压和血管并发症遗传决定因素的研究都集中在单个基因的作用上。这些研究往往得出相互矛盾的结果。因此，我们研究了三种肾素-血管紧张素系统（RAS）基因和三种盐敏感性基因对总体人群和2型糖尿病患者血压和动脉粥样硬化的联合作用。该研究是基于人群的队列研究——鹿特丹研究的一部分。我们对三种RAS基因多态性和三种盐敏感性基因多态性进行了基因分型。具有三种RAS基因风险基因型的糖尿病患者的收缩压比未携带任何风险基因型的患者高6.9 mmHg（趋势P = 0.04），脉压高6.0 mmHg（趋势P = 0.03）。具有三种盐敏感性基因风险基因型的糖尿病患者的收缩压高9.0 mmHg（P = 0.19），脉压高13.1 mmHg（P = 0.02）。携带三种RAS基因风险基因型的糖尿病患者的平均内膜中层厚度高于具有两种风险基因型的患者（平均差异0.04 mm，P = 0.02）。我们发现，在2型糖尿病患者中，平均收缩压、脉压和高血压风险随着RAS基因和盐敏感性基因风险基因型数量的增加而增加。
