Ha-Kawa S K, Tanaka Y
Department of Radiology, Kansai Medical University, Moriguchi, Japan.
J Nucl Med. 1991 Dec;32(12):2233-40.
Technetium-99m-diethylenetriaminepentaacetic acid-galactosyl-human serum albumin (99mTc-GSA) was studied in normal volunteers and in patients with impaired liver function. The extrapolation approach originated the absolute dose of 99mTc-GSA in blood and the hepatic blood volume. The heart and liver regression curves were simultaneously fractionated into the three compartments (extrahepatic blood, hepatic blood and hepatocytes). Four differential equations were integrated with the six parameters as variables, and the smallest residual sum of squares was obtained by the damping Gauss-Newton method. The result of hepatic blood flow was 1603 +/- 144 (ml/min) in normal controls, which was compatible with previously reported values. Maximal removal rate (mg/min) showed statistically significant differences between the normal volunteers and patients with chronic hepatitis or liver cirrhosis. Our kinetic model of 99mTc-GSA can be used in the evaluation of liver function.
对锝-99m-二乙烯三胺五乙酸-半乳糖基人血清白蛋白（99mTc-GSA）在正常志愿者和肝功能受损患者中进行了研究。外推法得出了血液中99mTc-GSA的绝对剂量和肝血容量。心脏和肝脏的回归曲线同时被划分为三个部分（肝外血液、肝血和肝细胞）。以六个参数为变量对四个微分方程进行积分，并通过阻尼高斯-牛顿法获得最小残差平方和。正常对照组的肝血流结果为1603±144（ml/分钟），这与先前报道的值相符。正常志愿者与慢性肝炎或肝硬化患者之间的最大清除率（mg/分钟）存在统计学显著差异。我们的99mTc-GSA动力学模型可用于肝功能评估。
