Specht H D, Bakke A C, Braziel R, Miley A, Rashidi-Nezami S, Germain L
Department of Radiology, Oregon Health Sciences University, Portland.
J Nucl Med. 1991 Dec;32(12):2288-90.
A patient with high levels of serum rheumatoid factor and an open lung biopsy which showed high-grade interstitial pneumonia with large numbers of lymphocytes and plasmocytes had intense gallium uptake in the lungs. Lymphocytes and/or plasmocytes might be responsible for the gallium uptake even though neutrophils are usually credited with high-level uptake. Differential cell counts demonstrated plasmocyte and lymphocyte preponderance, but neutrophil paucity. In vitro cell cultures of purified neutrophils, monocytes, leukemic plasmocytes, and resting and stimulated lymphocytes with 67Ga showed that plasmocytes take up comparatively low levels of 67Ga, but that activated lymphocytes take up levels that approach neutrophils. It is probable that both rheumatoid lung plasmocytes and activated lymphocytes are responsible for the pulmonary 67Ga concentration in this patient.
一名血清类风湿因子水平较高的患者，其开放性肺活检显示为高级别间质性肺炎，伴有大量淋巴细胞和浆细胞，肺部有强烈的镓摄取。淋巴细胞和/或浆细胞可能是镓摄取的原因，尽管通常认为中性粒细胞具有高水平摄取。细胞分类计数显示浆细胞和淋巴细胞占优势，而中性粒细胞缺乏。用67Ga对纯化的中性粒细胞、单核细胞、白血病浆细胞以及静息和活化淋巴细胞进行的体外细胞培养表明，浆细胞摄取的67Ga水平相对较低，但活化淋巴细胞摄取的水平接近中性粒细胞。很可能类风湿性肺病的浆细胞和活化淋巴细胞都是该患者肺部67Ga浓度升高的原因。
