Blumenthal Robert, Dimitrov Dimiter S
Center for Cancer Research Nanobiology Program, NCI-Frederick, NIH, Frederick, MD 21702-1201, USA.
Cell. 2007 Apr 20;129(2):243-5. doi: 10.1016/j.cell.2007.04.005.
Although human blood plasma contains molecules that inhibit the activity of HIV-1, their identity is largely unknown. Münch et al. (2007) now identify a peptide corresponding to a portion of alpha1-antitrypsin that potently inhibits entry of HIV-1 into host cells by binding to a hydrophobic segment of the viral envelope glycoprotein gp41.
尽管人类血浆中含有抑制HIV-1活性的分子，但其具体成分大多未知。Münch等人（2007年）现已鉴定出一种与α1-抗胰蛋白酶一部分相对应的肽，该肽通过与病毒包膜糖蛋白gp41的疏水片段结合，有效抑制HIV-1进入宿主细胞。
