Voglmaier Susan M, Edwards Robert H
Department of Psychiatry, UCSF School of Medicine, 600 16th Street, San Francisco, CA 94158-2517, USA.
Curr Opin Neurobiol. 2007 Jun;17(3):374-80. doi: 10.1016/j.conb.2007.04.002. Epub 2007 Apr 20.
At a wide range of synapses, synaptic vesicles reside in distinct pools that respond to different stimuli. The recycling pool supplies the vesicles required for release in response to modest stimulation, whereas the reserve pool is mobilized only by strong stimulation. Multiple pathways have been proposed for the recycling of synaptic vesicles after exocytosis, but the relationship of these pathways to the different synaptic vesicle pools has remained unclear. Synaptic vesicle proteins have also been assumed to undergo recycling as a unit. However, emerging data indicate that differences in the association with distinct endocytic adaptors such as the heterotetrameric adaptor AP3 influence the trafficking of individual synaptic vesicle proteins, affecting the composition of synaptic vesicles and hence their functional characteristics. These observations might begin to account for differences in the properties of different vesicle pools.
在多种突触中，突触小泡存在于不同的池中，对不同刺激做出反应。回收池提供适度刺激时释放所需的小泡，而储备池仅在强烈刺激时才被动员。胞吐作用后突触小泡的回收已提出多种途径，但这些途径与不同突触小泡池的关系仍不清楚。突触小泡蛋白也被认为作为一个整体进行回收。然而，新出现的数据表明，与不同内吞衔接蛋白（如异源四聚体衔接蛋白AP3）的结合差异会影响单个突触小泡蛋白的运输，影响突触小泡的组成，进而影响其功能特性。这些观察结果可能开始解释不同小泡池特性的差异。
