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锝-99m标记与胸苷类似物的合成：肿瘤成像的潜在候选物

Technetium-99m-labeling and synthesis of thymidine analogs: potential candidates for tumor imaging.

作者信息

Teng Bao, Bai Yunpeng, Chang Yu, Chen Shizhen, Li Zhaolong

机构信息

Department of Chemistry, Tsinghua University, Beijing 100084, PR China.

出版信息

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3440-4. doi: 10.1016/j.bmcl.2007.03.086. Epub 2007 Mar 30.

DOI:10.1016/j.bmcl.2007.03.086
PMID:17449246
Abstract

The technetium-99m-labeling and synthesis of a series of thymidine analogs were studied. The target molecules were obtained by using 6-hydrazinopyridine-3-carboxylic acid (HYNIC) as a bifunctional coupling agent and using N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine (tricine) and ethylenediamine-N,N'-diacetic acid (EDDA) as coligands. The effects of different spacers between thymidine analog with HYNIC on radiochemical yield were also studied.

摘要

研究了一系列胸苷类似物的锝-99m标记与合成。以6-肼基吡啶-3-羧酸（HYNIC）作为双功能偶联剂，N-(2-羟基-1,1-双(羟甲基)乙基)甘氨酸（三(羟甲基)氨基甲烷）和乙二胺-N,N'-二乙酸（EDDA）作为共配体，得到了目标分子。还研究了胸苷类似物与HYNIC之间不同间隔基对放射化学产率的影响。

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