Kuribara H, Asashi T, Tadokoro S
Division for Behavior Analysis, Gunma University School of Medicine, Maebashi, Japan.
Jpn J Pharmacol. 1991 Aug;56(4):457-63. doi: 10.1254/jjp.56.457.
The interaction between opioid analgesics (morphine and buprenorphine) and central depressants (ethanol, pentobarbital and diazepam) was investigated by means of ambulatory activity in mice. The ambulation-increasing effect of both morphine (10 mg/kg, s.c.) and buprenorphine (1 mg/kg, s.c.) was enhanced by the combined administration of ethanol (0.8-3.2 g/kg, p.o.) in a dose-dependent manner. Naloxone (0.1 mg/kg, s.c.) was effective for reducing the enhanced ambulatory activity. The pretreatment with Ca-cyanamide (5 mg/kg, p.o., 30 min before) reduced the enhancement of the ambulation-increasing effect induced by the combined administration of opioid analgesics with ethanol, although it scarcely modified that of morphine and buprenorphine alone. On the other hand, neither pentobarbital (1-30 mg/kg, s.c.) nor diazepam (0.25-2 mg/kg, s.c.) modified markedly the ambulation-increasing effect of morphine and buprenorphine. The present results suggest that ethanol specifically interacted with opioid analgesics when the mouse's ambulatory activity was used as the indicator.
通过小鼠的自主活动来研究阿片类镇痛药（吗啡和丁丙诺啡）与中枢抑制剂（乙醇、戊巴比妥和地西泮）之间的相互作用。乙醇（0.8 - 3.2 g/kg，口服）联合给药可剂量依赖性地增强吗啡（10 mg/kg，皮下注射）和丁丙诺啡（1 mg/kg，皮下注射）的促自主活动作用。纳洛酮（0.1 mg/kg，皮下注射）可有效降低增强的自主活动。氰胺钙预处理（5 mg/kg，口服，提前30分钟）可降低阿片类镇痛药与乙醇联合给药诱导的促自主活动作用增强，尽管它对单独使用吗啡和丁丙诺啡的作用几乎没有影响。另一方面，戊巴比妥（1 - 30 mg/kg，皮下注射）和地西泮（0.25 - 2 mg/kg，皮下注射）均未显著改变吗啡和丁丙诺啡的促自主活动作用。目前的结果表明，当以小鼠的自主活动作为指标时，乙醇与阿片类镇痛药存在特异性相互作用。
