吸烟所致肺气肿中的抗弹性蛋白自身免疫

Antielastin autoimmunity in tobacco smoking-induced emphysema.

作者信息

Lee Seung-Hyo, Goswami Sangeeta, Grudo Ariel, Song Li-Zhen, Bandi Venkata, Goodnight-White Sheila, Green Linda, Hacken-Bitar Joan, Huh Joseph, Bakaeen Faisal, Coxson Harvey O, Cogswell Sebastian, Storness-Bliss Claudine, Corry David B, Kheradmand Farrah

机构信息

Department of Medicine, Section of Pulmonary and Critical Care, Baylor College of Medicine, Houston, Texas 77030, USA.

出版信息

Nat Med. 2007 May;13(5):567-9. doi: 10.1038/nm1583. Epub 2007 Apr 22.

DOI:10.1038/nm1583

PMID:17450149

Abstract

Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (T(H)1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.

摘要

慢性阻塞性肺疾病和肺气肿是常见的破坏性炎症性疾病，是全球范围内的主要死因。我们在此表明，肺气肿是一种自身免疫性疾病，其特征是存在抗弹性蛋白抗体和1型辅助性T细胞（Th1）反应，这些反应与肺气肿的严重程度相关。这些发现将肺气肿与针对特定肺抗原的适应性免疫联系起来，并提示其他富含弹性蛋白的组织，如吸烟者的动脉和皮肤，可能存在自身免疫病理改变。