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评估视神经和视网膜神经纤维层:海德堡视网膜断层扫描、扫描激光偏振仪及光学相干断层扫描的作用

Evaluating the optic nerve and retinal nerve fibre layer: the roles of Heidelberg retina tomography, scanning laser polarimetry and optical coherence tomography.

作者信息

Hoh Sek-Tien

机构信息

Singapore National Eye Centre, Singapore.

出版信息

Ann Acad Med Singap. 2007 Mar;36(3):194-202.

Abstract

INTRODUCTION

For many years, ophthalmologists have looked at the optic nerve head to evaluate the status of glaucoma. Clinical examination of the optic nerve head and retinal nerve fibre layer (RNFL) is however, subjective and sometimes variable. Recent developments in computer-based imaging technologies have provided a means of obtaining quantitative measurements of the optic nerve head topography and peripapillary retinal nerve fibre layer thickness.

METHODS

Multiple searches using Medline were carried out. Additional searches were made using reference lists of published papers and book chapters.

RESULTS

Studies involving three imaging technologies namely, confocal scanning laser ophthalmoscopy, scanning laser polarimetry and optical coherence tomography were reviewed. Overall, these technologies were reproducible and demonstrate good sensitivity and specificity in the range of 70 to 80%. Inclusion of age and ethnicity normative database will make these technologies more effective in screening and diagnosis. Quantitative measurements provide useful parameters for monitoring of patients.

CONCLUSION

There is no consensus on the best technology for assessing structural damage in glaucomatous optic neuropathy. Therefore, as with any investigation, the clinician should exercise clinical correlation and judgment before instituting the appropriate treatment.

摘要

引言

多年来,眼科医生一直通过观察视神经乳头来评估青光眼的病情。然而,对视神经乳头和视网膜神经纤维层(RNFL)的临床检查具有主观性,且有时存在差异。基于计算机的成像技术的最新进展提供了一种对视神经乳头地形图和视乳头周围视网膜神经纤维层厚度进行定量测量的方法。

方法

使用医学文献数据库(Medline)进行了多次检索。还利用已发表论文和书籍章节的参考文献列表进行了额外检索。

结果

对涉及三种成像技术的研究进行了综述,这三种技术分别是共焦扫描激光 ophthalmoscopy、扫描激光偏振仪和光学相干断层扫描。总体而言,这些技术具有可重复性,在70%至80%的范围内显示出良好的敏感性和特异性。纳入年龄和种族规范数据库将使这些技术在筛查和诊断中更有效。定量测量为监测患者提供了有用的参数。

结论

对于评估青光眼性视神经病变结构损伤的最佳技术尚无共识。因此,与任何检查一样临床医生在采取适当治疗之前应进行临床关联并做出判断。

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