Hoh S T, Greenfield D S, Mistlberger A, Liebmann J M, Ishikawa H, Ritch R
Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York, USA.
Am J Ophthalmol. 2000 Feb;129(2):129-35. doi: 10.1016/s0002-9394(99)00294-9.
To evaluate the relationship between visual function and retinal nerve fiber layer measurements obtained with scanning laser polarimetry and optical coherence tomography in a masked, prospective trial.
Consecutive normal, ocular hypertensive, and glaucomatous subjects who met inclusion and exclusion criteria were evaluated. Complete ophthalmologic examination, disk photography, scanning laser polarimetry, optical coherence tomography, and automated achromatic perimetry were performed.
Seventy-eight eyes of 78 patients (17 normal, 23 ocular hypertensive, and 38 glaucomatous) were enrolled (mean age, 56.8+/-11.5 years; range, 26 to 75 years). Eyes with glaucoma had significantly greater neural network scores on scanning laser polarimetry and lower maximum modulation, ellipse modulation, and mean retinal nerve fiber layer thickness measured with optical coherence tomography compared with normal and ocular hypertensive eyes, respectively (all P<.005). Significant associations were observed between neural network number (r = -.51, r = .03), maximum modulation (r = .39, r = -.32), ellipse modulation (r = .36, r = -.28), and optical coherence tomography-generated retinal nerve fiber layer thickness (r = .68, r = -.59) and visual field mean deviation and corrected pattern standard deviation, respectively. All scanning laser polarimetry parameters were significantly associated with optical coherence tomography-generated retinal nerve fiber layer thickness.
Optical coherence tomography and scanning laser polarimetry were capable of differentiating glaucomatous from nonglaucomatous populations in this cohort; however considerable measurement overlap was observed among normal, ocular hypertensive, and glaucomatous eyes. Retinal nerve fiber layer structural measurements demonstrated good correlation with visual function, and retinal nerve fiber layer thickness by optical coherence tomography correlated with retardation measurements by scanning laser polarimetry.
在一项遮蔽的前瞻性试验中，评估扫描激光偏振仪和光学相干断层扫描所测得的视觉功能与视网膜神经纤维层测量值之间的关系。
对符合纳入和排除标准的连续正常、高眼压和青光眼患者进行评估。进行了全面的眼科检查、视盘照相、扫描激光偏振仪检查、光学相干断层扫描和自动消色差视野检查。
纳入了78例患者的78只眼（17例正常、23例高眼压和38例青光眼）（平均年龄56.8±11.5岁；范围26至75岁）。与正常眼和高眼压眼相比，青光眼患者的眼在扫描激光偏振仪上的神经网络得分显著更高，而在光学相干断层扫描中测得的最大调制、椭圆调制和平均视网膜神经纤维层厚度则更低（均P<0.005）。分别观察到神经网络数量（r = -0.51，r = 0.03）、最大调制（r = 0.39，r = -0.32）、椭圆调制（r = 0.36，r = -0.28）以及光学相干断层扫描生成的视网膜神经纤维层厚度（r = 0.68，r = -0.59）与视野平均偏差和校正模式标准差之间存在显著相关性。所有扫描激光偏振仪参数均与光学相干断层扫描生成的视网膜神经纤维层厚度显著相关。
在该队列中，光学相干断层扫描和扫描激光偏振仪能够区分青光眼患者和非青光眼患者；然而，在正常眼、高眼压眼和青光眼眼中观察到了相当大的测量重叠。视网膜神经纤维层结构测量与视觉功能显示出良好的相关性，并且光学相干断层扫描测得的视网膜神经纤维层厚度与扫描激光偏振仪测得的延迟测量值相关。
