Hrabovszky Erik, Liposits Zsolt
Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest.
Ideggyogy Sz. 2007 Mar 30;60(3-4):182-6.
While three decades ago, the co-existence of classical neurotransmitters and peptide neuromodulators in a single neuronal cell was considered to be rather exceptional, the phenomenon that neurons have a complex transmitter phenotype now appears to be the general rule. Parvicellular and magnocellular neurosecretory systems consist of neuronal cells which are specialized in secreting peptide neurohormones into the blood-stream to regulate hypophyseal functions. This mini-review, dedicated to the memory of Mariann Fodor, summarizes the current knowledge about the classical neurotransmitter content of different hypothalamic neurosecretory systems, with a special focus on the occurrence and putative functions of glutamate in parvicellular and magnocellular neurosecretory cells.
三十年前，人们认为单个神经元细胞中经典神经递质和肽类神经调质共存的情况相当罕见，但现在神经元具有复杂递质表型这一现象似乎已成为普遍规律。小细胞和大细胞神经分泌系统由专门将肽类神经激素分泌到血流中以调节垂体功能的神经元细胞组成。这篇献给玛丽安·福多尔的简短综述总结了目前关于不同下丘脑神经分泌系统经典神经递质含量的知识，特别关注谷氨酸在小细胞和大细胞神经分泌细胞中的存在情况及假定功能。
