Melcer Shai, Gruenbaum Yosef, Krohne Georg
Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Exp Cell Res. 2007 Jun 10;313(10):2157-66. doi: 10.1016/j.yexcr.2007.03.004. Epub 2007 Mar 15.
Lamins are the main component of the nuclear lamina and considered to be the ancestors of all intermediate filament proteins. They are localized mainly at the nuclear periphery where they form protein complexes with integral proteins of the nuclear inner membrane, transcriptional regulators, histones and chromatin modifiers. Studying lamins in invertebrate species has unique advantages including the smaller number of lamin genes in the invertebrate genomes and powerful genetic analyses in Caenorhabditis elegans and Drosophila melanogaster. These simpler nuclear lamina systems allow direct analyses of their structure and functions. Here we give an overview of recent advances in the field of invertebrate nuclear lamins with special emphasis on their evolution, assembly and functions.
核纤层蛋白是核纤层的主要成分，被认为是所有中间丝蛋白的祖先。它们主要定位于核周，在那里与核内膜的整合蛋白、转录调节因子、组蛋白和染色质修饰因子形成蛋白质复合物。研究无脊椎动物中的核纤层蛋白具有独特的优势，包括无脊椎动物基因组中核纤层蛋白基因数量较少，以及在秀丽隐杆线虫和黑腹果蝇中强大的遗传分析能力。这些更简单的核纤层系统允许直接分析它们的结构和功能。在这里，我们概述了无脊椎动物核纤层蛋白领域的最新进展，特别强调它们的进化、组装和功能。
