Claudel Thierry, Cretenet Gaspard, Saumet Anne, Gachon Frédéric
Department of Pediatrics, Research Laboratory, University Medical Center Groningen, Groningen, ND-9700 RB, The Netherlands.
FEBS Lett. 2007 Jul 31;581(19):3626-33. doi: 10.1016/j.febslet.2007.04.009. Epub 2007 Apr 17.
Many aspects of physiology and behavior in organisms from bacteria to man are subjected to circadian regulation. Indeed, the major function of the circadian clock consists in the adaptation of physiology to daily environmental change and the accompanying stresses such as exposition to UV-light and food-contained toxic compounds. In this way, most aspects of xenobiotic detoxification are subjected to circadian regulation. These phenomena are now considered as the molecular basis for the time-dependence of drug toxicities and efficacy. However, there is now evidences that these toxic compounds can, in turn, regulate circadian gene expression and thus influence circadian rhythms. As food seems to be the major regulator of peripheral clock, the possibility that food-contained toxic compounds participate in the entrainment of the clock will be discussed.
从细菌到人类，生物体的生理和行为的许多方面都受到昼夜节律调节。事实上，生物钟的主要功能在于使生理机能适应日常环境变化以及随之而来的压力，如暴露于紫外线和食物中含有的有毒化合物。通过这种方式，大多数外源性物质解毒的方面都受到昼夜节律调节。这些现象现在被认为是药物毒性和疗效时间依赖性的分子基础。然而，现在有证据表明，这些有毒化合物反过来可以调节昼夜节律基因的表达，从而影响昼夜节律。由于食物似乎是外周生物钟的主要调节因子，因此将讨论食物中含有的有毒化合物参与生物钟同步的可能性。
