Mackinnon S E, Dellon A L, O'Brien J P
Johns Hopkins University, Baltimore, Maryland.
Muscle Nerve. 1991 Nov;14(11):1116-22. doi: 10.1002/mus.880141113.
Changes in nerve fiber numbers distal to a nerve repair in the sciatic nerve of 48 rats were evaluated over a 1- to 24-month period. The results of the morphometric evaluation in the sciatic nerve distal to the nerve repair demonstrated an increase in nerve fiber counts as early as 1 month following the nerve repair. The number of nerve fibers in the distal nerve was greatest at 3 months and did not return to normal levels until 24 months. The results of this study will influence the timing of experimental studies in which nerve fiber counts are critical for evaluation, and provides a better understanding of the clinical events occurring following nerve repair.
在48只大鼠的坐骨神经中，对神经修复远端的神经纤维数量变化进行了1至24个月的评估。神经修复远端坐骨神经的形态学评估结果表明，神经修复后1个月神经纤维数量就开始增加。远端神经中的神经纤维数量在3个月时最多，直到24个月才恢复到正常水平。本研究结果将影响神经纤维计数对评估至关重要的实验研究的时间安排，并有助于更好地理解神经修复后发生的临床事件。
