Polleux Franck, Ince-Dunn Gulayse, Ghosh Anirvan
Neuroscience Center, Department of Pharmacology, Neurodevelopmental Diseases Research Center, University of North Carolina, Chapel Hill, North Carolina 27599-7250, USA.
Nat Rev Neurosci. 2007 May;8(5):331-40. doi: 10.1038/nrn2118.
The establishment of functional neural connections requires the growth of axons to specific target areas and the formation of synapses with appropriate synaptic partners. Several molecules that regulate axon guidance and synapse formation have been identified in the past decade, but it is unclear how a relatively limited number of factors can specify a large number of connections. Recent evidence indicates that transcription factors make a crucial contribution to the specification of connections in the nervous system by coordinating the response of neurons to guidance molecules and neurotransmitters.
功能性神经连接的建立需要轴突生长至特定的靶区域，并与合适的突触伙伴形成突触。在过去十年中，已经鉴定出了几种调节轴突导向和突触形成的分子，但尚不清楚相对有限数量的因子如何能够确定大量的连接。最近的证据表明，转录因子通过协调神经元对导向分子和神经递质的反应，对神经系统中连接的特异性做出了关键贡献。
