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早产儿脑瘫的早期标志物及临床研究

Earlier markers for cerebral palsy and clinical research in premature infants.

作者信息

Donohue P K, Graham E M

机构信息

Department of Pediatrics, Eudowood Division of Neonatology, Johns Hopkins School of Medicine, Johns Hopkins University Schools of Medicine and Public Health, Baltimore, MD, USA.

出版信息

J Perinatol. 2007 May;27(5):259-61. doi: 10.1038/sj.jp.7211741.

Abstract

The diagnosis of cerebral palsy is based on evidence of impairment of the motor system, but symptoms become evident only as a premature infant matures. The diagnosis is made typically at 18 to 24 months of age, corrected for gestational age at birth. An earlier and more accurate way to identify infants destined to develop cerebral palsy may help improve the prognosis for this vulnerable population. For now, no antenatal, perinatal or postnatal test can predict cerebral palsy with a degree of certainty high enough to help providers or parents plan for an infant's future or make the best use of early intervention resources.

摘要

脑瘫的诊断基于运动系统受损的证据,但症状只有在早产儿成熟时才会显现出来。诊断通常在出生后18至24个月进行,并根据出生时的孕周进行校正。一种更早且更准确地识别注定会发展为脑瘫的婴儿的方法,可能有助于改善这一弱势群体的预后。目前,没有任何产前、围产期或产后检查能够以足够高的确定性预测脑瘫,从而帮助医疗服务提供者或家长为婴儿的未来制定计划,或充分利用早期干预资源。

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