Fica C Alberto, Jadue A Carla, Donaire R Luisa
Sección de Infectología, Hospital Clínico, Universidad de Chile, Departamento de Medicina, Santiago, Chile.
Rev Chilena Infectol. 2007 Apr;24(2):106-10. doi: 10.4067/s0716-10182007000200003. Epub 2007 Apr 12.
Medical prescription errors are frequent in community settings and information exploring its magnitude during antiviral treatment of herpes zoster is scarce. A questionnaire was applied to 31 physicians working in hospital- or community-based settings in Santiago, Chile in order to characterize their dosing and timing preferences for aciclovir or valaciclovir prescriptions. Aciclovir was more often prescribed than valaciclovir (71.9 and 28.1%, respectively), but less than a third of prescription (27.3%) fulfilled the minimal aciclovir dosing and timing criteria for clinical efficacy (4 gr per day and <72 hours since rash initiation). The limited size of the simple prevented exploring factors linked to a misleading prescription. Appropriate knowledge on dosing and timing of aciclovir/valaciclovir therapy for herpes zoster was infrequent in a sample of physicians working in various clinical settings in Chile.
医疗处方错误在社区环境中很常见，而关于带状疱疹抗病毒治疗期间其严重程度的信息却很少。对智利圣地亚哥31名在医院或社区工作的医生进行了问卷调查，以了解他们对阿昔洛韦或伐昔洛韦处方的剂量和时间偏好。阿昔洛韦的处方频率高于伐昔洛韦（分别为71.9%和28.1%），但不到三分之一的处方（27.3%）符合阿昔洛韦临床疗效的最小剂量和时间标准（每天4克，出疹后<72小时）。样本量有限妨碍了对与错误处方相关因素的探究。在智利不同临床环境工作的医生样本中，对阿昔洛韦/伐昔洛韦治疗带状疱疹的剂量和时间的适当知识并不常见。
