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[心脏、老年人与糖尿病。333例门诊临床病例的流行病学研究]

[The heart, the elderly, and diabetes mellitus. Epidemiologic study of 333 ambulatory clinical cases].

作者信息

Tamburrini L R, Di Monte M, Ponte E, Vriz O

机构信息

II Cattedra di Geriatria e Gerontologia, Università degli Studi, Ospedale S. Santorio, Trieste.

出版信息

Minerva Med. 1991 Oct;82(10):665-73.

PMID:1745377
Abstract

The paper proposes a new classification to describe the normal senile heart and its pathological forms: "small aortic heart" (nonhypertrophic-dilatative myocardiopathy and its ischemic form) and "large aortic heart" (hypertrophic-dilatative myocardiopathy and its ischemic form). The statistical distribution of 241 elderly patients with diabetes mellitus using this classification was compared to a control group of 92 elderly non-diabetic subjects. The results reveal the significant epidemiological incidence of ischemic cardiopathy with small aortic heart in diabetic patients compared to the control group in which more ischemic hypertrophic-dilatative cardiopathies were present. This observation supports the hypothesis that senile diabetic cardiopathy begins with a metabolic block with reduced contractile energy, and the overlying important ischemic component leads to the development of the small-size clinical phenotype.

摘要

本文提出了一种新的分类方法来描述正常老年心脏及其病理形式

“小主动脉型心脏”(非肥厚性扩张型心肌病及其缺血性形式)和“大主动脉型心脏”(肥厚性扩张型心肌病及其缺血性形式)。将使用该分类方法的241例老年糖尿病患者的统计分布与92例老年非糖尿病受试者的对照组进行了比较。结果显示,与对照组相比,糖尿病患者中小主动脉型心脏的缺血性心脏病的流行病学发病率显著更高,对照组中存在更多的缺血性肥厚性扩张型心肌病。这一观察结果支持了以下假设:老年糖尿病性心脏病始于代谢阻滞,收缩能量降低,而重要的缺血成分叠加导致小尺寸临床表型的发展。

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