Altan-Yaycioglu Rana, Yaycioglu Ozgur, Tufan Hale, Akova Yonca A, Ozkardes Hakan
Department of Ophthalmology, Baskent University, Ankara, Turkey.
Curr Eye Res. 2007 Mar;32(3):217-21. doi: 10.1080/02713680601174173.
To investigate the effects of alpha-1 adrenergic blockers on pupil diameter (PD) in rats.
Four groups, with 10 rats each, were designed to receive terazosin, tamsulosin, doxazosin, and no medication. Dilated pupil diameter (PD) measurements were performed 24 hr before, 24 hr after, and 30 days after the initiation of medication, and after 30 days of washout. The intergroup and intragroup differences in PD were evaluated using one-way ANOVA and Wilcoxon signed rank test, respectively.
In day 1, PD decreased in both eyes significantly only in tamsulosin and doxazosin groups, but these effects became insignificant at 30 days of treatment (p > 0.05). The control group showed no significant difference in PD (p > 0.05). PD values returned to baseline after the washout period in all groups.
A significant reduction in PD occurred in two of the three groups with alpha-1 adrenergic blockers (tamsulosin and doxazosin), but this effect was not sustained at 30 days. Further functional and structural studies of the iris are needed to determine the clinical significance of these findings.
研究α-1肾上腺素能阻滞剂对大鼠瞳孔直径（PD）的影响。
设计四组，每组10只大鼠，分别接受特拉唑嗪、坦索罗辛、多沙唑嗪治疗，另一组不接受药物治疗。在用药开始前24小时、用药后24小时、用药后30天以及停药30天后测量瞳孔直径（PD）。分别采用单因素方差分析和Wilcoxon符号秩检验评估组间和组内PD的差异。
在第1天，仅坦索罗辛组和多沙唑嗪组的双眼PD显著降低，但在治疗30天时这些影响变得不显著（p>0.05）。对照组的PD无显著差异（p>0.05）。所有组在停药期后PD值均恢复到基线水平。
在使用α-1肾上腺素能阻滞剂的三组中，有两组（坦索罗辛和多沙唑嗪）的PD显著降低，但这种效果在30天时未持续。需要对虹膜进行进一步的功能和结构研究，以确定这些发现的临床意义。
