Lo Yung-Kuang, Chen Chiu-Ju, Tsai Tong-Rong, Cham Thau-Ming
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, San Min District, Kaohsiung City, Taiwan, ROC.
Drug Dev Ind Pharm. 2007 Mar;33(3):301-9. doi: 10.1080/03639040600920622.
The solid complex of gliclazide and beta-cyclodextrin was prepared by neutralization method and the precipitation solvent evaporation method was used to prepare gliclazide nanospheres. Fourier-transform infrared spectroscopy and differential scanning calorimetry were used to examine whether gliclazide solid complex and gliclazide nanospheres were successfully formed in this study. The dissolution rate of gliclazide from its nanospheres was faster than its solid complex and pure drug. The morphology of particles for nanospheres showed no crystal character of gliclazide. In summary, the results indicate that nanotechnology provides better effects in solubility and dissolution rate of gliclazide than neutralization method.
采用中和法制备了格列齐特与β-环糊精的固体复合物，并用沉淀溶剂蒸发法制备了格列齐特纳米球。本研究采用傅里叶变换红外光谱和差示扫描量热法检测格列齐特固体复合物和纳米球是否成功形成。格列齐特从其纳米球中的溶出速率比其固体复合物和纯药物更快。纳米球颗粒的形态显示不出格列齐特的晶体特征。总之，结果表明纳米技术在格列齐特的溶解度和溶出速率方面比中和法具有更好的效果。
