Schneider P F, Riley T V
Western Diagnostic Pathology, Myaree, Western Australia.
Pathology. 1991 Apr;23(2):135-8. doi: 10.3109/00313029109060812.
The minimum inhibitory concentrations (MICs) of 10 antimicrobial agents for 96 urinary isolates of Staphylococcus saprophyticus cultured from symptomatic females in the Western Australian general community are reported. All antimicrobial agents tested showed good activity, with the exceptions of norfloxacin (MIC90 8 mg/L) and ampicillin (MIC90 0.5 mg/L). Eighty-three of 96 isolates were susceptible to all antimicrobial agents tested. One isolate was resistant to both tetracycline and trimethoprim. The remainder were resistant to a single antimicrobial agent; 10 to tetracycline and 2 to trimethoprim. None of the isolates exhibited any detectable beta-lactamase activity when tested by the chromogenic cephalosporin method. Synergy between trimethoprim and sulphafurazole against Staph. saprophyticus was demonstrated in only 2 of 5 strains having an increased MIC of one or both of these agents.
本文报道了从西澳大利亚普通社区有症状女性中培养出的96株腐生葡萄球菌尿液分离株对10种抗菌药物的最低抑菌浓度（MIC）。除诺氟沙星（MIC90为8mg/L）和氨苄西林（MIC90为0.5mg/L）外，所有测试的抗菌药物均显示出良好的活性。96株分离株中有83株对所有测试的抗菌药物敏感。1株分离株对四环素和甲氧苄啶均耐药。其余分离株对单一抗菌药物耐药；10株对四环素耐药，2株对甲氧苄啶耐药。当采用显色头孢菌素法检测时，所有分离株均未表现出任何可检测到的β-内酰胺酶活性。在5株对甲氧苄啶或磺胺异恶唑中一种或两种药物的MIC升高的菌株中，仅2株显示出甲氧苄啶和磺胺异恶唑对腐生葡萄球菌的协同作用。
