Masarei J R, Puddey I B, Vandongen R, Beilin L J, Lynch W J
Department of Medicine, University of Western Australia, Perth.
Pathology. 1991 Apr;23(2):98-102. doi: 10.3109/00313029109060805.
This study investigated the effects of 6 weeks' smoking cessation on serum levels of total-cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C) and apolipoproteins A-I and A-II (apo A-I and apo A-II) in 64 subjects of both sexes. Smoking cessation was associated with an increase in levels of apo A-II. Concurrent changes in weight and alcohol consumption during attempted smoking cessation, together with change in thiocyanate level, were entered as predictor variables into a multiple regression analysis. The change in apo A-II was found to be best accounted for by change in plasma thiocyanate level, and, in women, change in HDL-C and apo A-I by change in weight. The changes induced by smoking cessation may be due, at least in part, to associated changes in alcohol consumption and/or dietary intake, but in the case of apo A-II there is evidence of a more direct effect.
本研究调查了64名男女受试者戒烟6周对血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇（HDL-C）以及载脂蛋白A-I和A-II（apo A-I和apo A-II）水平的影响。戒烟与apo A-II水平升高有关。在尝试戒烟期间体重和酒精摄入量的同时变化，以及硫氰酸盐水平的变化，作为预测变量纳入多元回归分析。发现apo A-II的变化最能由血浆硫氰酸盐水平的变化来解释，而在女性中，HDL-C和apo A-I的变化则由体重变化来解释。戒烟引起的变化可能至少部分归因于酒精摄入量和/或饮食摄入量的相关变化，但就apo A-II而言，有证据表明存在更直接的影响。
