Culine Stéphane
Centre régional de lutte contre le cancer Val d'Aurelle, Montpellier Cedex.
Rev Prat. 2007 Feb 28;57(4):385-8.
The gold standard regimen for metastatic testicular germ cell tumours is a combination of bleomycin, etoposide and cisplatin. The number of cycles is defined by pathology (seminoma or non seminoma) and the prognostic criteria of the international classification (degree of elevation of serum tumour markers and presence or not of non pulmonary visceral metastases). The surgical resection of all residual metastatic masses is mandatory after the normalization of serum tumour markers in non seminoma patients. The cure rates after chemotherapy and surgery are about 90% and 50% in good-risk and poor-risk patients, respectively.
转移性睾丸生殖细胞肿瘤的金标准治疗方案是博来霉素、依托泊苷和顺铂联合使用。化疗周期数由病理类型(精原细胞瘤或非精原细胞瘤)以及国际分类的预后标准(血清肿瘤标志物升高程度和是否存在非肺内脏转移)来确定。对于非精原细胞瘤患者,在血清肿瘤标志物恢复正常后,必须对所有残留的转移瘤进行手术切除。低危和高危患者化疗及手术后的治愈率分别约为90%和50%。