Bucciarelli E, Cavaliere A
Institute of Pathological Anatomy and Histology, First Chair, Perugia University.
Pathologica. 1991 Mar-Apr;83(1084):223-7.
We report a case of primary malignant lymphoma of the central nervous system found in a 69-year old woman suffering from Parkinson's disease and hypertension. The CAT scan revealed an ill defined lesion in the left frontal lobe which at surgery appeared as a brownish-black friable neoformation. The histologic exam revealed a proliferation of voluminous round lymphoid cells with 2 or 3 nucleoli often apposed to the nuclear membrane. At the immunohistochemical investigation they were positive for LC and L26 monoclonal antibodies. Malignant centroblastic B-cell lymphoma was diagnosed. All post-surgery investigations excluded the presence of neoplasms in other sites.
我们报告一例原发性中枢神经系统恶性淋巴瘤，患者为一名69岁患有帕金森病和高血压的女性。计算机断层扫描（CAT）显示左额叶有一个边界不清的病变，手术中该病变表现为棕黑色易碎的新生物。组织学检查显示大量圆形淋巴细胞增殖，有2或3个核仁，常靠近核膜。免疫组化检查显示它们对LC和L26单克隆抗体呈阳性。诊断为恶性中心母细胞性B细胞淋巴瘤。所有术后检查均排除了其他部位存在肿瘤的情况。
