Birdane Alparslan, Korkmaz Cengiz, Ata Necmi, Cavusoglu Yuksel, Kasifoglu Timucin, Dogan Sait Mesut, Gorenek Bulent, Goktekin Omer, Unalir Ahmet, Timuralp Bilgin
Department of Cardiology, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
Echocardiography. 2007 May;24(5):485-93. doi: 10.1111/j.1540-8175.2007.00422.x.
Previous studies have reported that cardiovascular involvement in rheumatoid arthritis (RA) occurs frequently. Although ventricular functions of RA have been investigated through the standard Doppler in RA, they have yet to be investigated thoroughly by means of the relatively new and advantageous tissue Doppler imaging (TDI). The present study aims to investigate left and right ventricular functions in RA patients by means of TDI and standard Doppler echocardiography.
A total of 60 patients with longstanding RA and 40 control subjects were included in the study and their left and right ventricular functions were assessed by standard pulsed-wave Doppler echocardiography, the color M-mode flow propagation velocity, and TDI. The left ventricular TDI was achieved at four different sites (lateral, septal, anterior, and inferior walls), while the right ventricular TDI was achieved through the tricuspid lateral annulus.
When compared with controls, the RA group showed that basal clinic and echocardiographic parameters, early (E) and late (A) diastolic velocities of atrioventricular valves, E/A ratio, and pulmonary venous Doppler parameters of these two groups were similar. It was determined that left and right ventricular E-wave deceleration times and isovolumic relaxation times of the RA patients were determined to have increased in comparison with those of the subjects in the healthy Control Group (P < 0.05). RA patients had significantly lower color M-mode flow propagation velocity (P < 0.05). While S' peak and E' peak, two of the left and right ventricular TDI parameters, were similar in both groups, A' peak, E'/A', and E/E' parameters in RA showed statistically significant differences in RA patients.
A comparison between age and sex of RA patients and healthy individuals revealed that left and right ventricular TDI parameters of RA patients were impaired, which led us to conclude that both of the ventricles could have been involved.
既往研究报道类风湿关节炎（RA）常出现心血管受累。虽然已通过标准多普勒对RA患者的心室功能进行了研究，但相对较新且具优势的组织多普勒成像（TDI）尚未对其进行深入研究。本研究旨在通过TDI和标准多普勒超声心动图研究RA患者的左、右心室功能。
本研究共纳入60例病程较长的RA患者和40例对照者，通过标准脉冲波多普勒超声心动图、彩色M型血流传播速度和TDI评估其左、右心室功能。左心室TDI在四个不同部位（侧壁、室间隔、前壁和下壁）进行，而右心室TDI通过三尖瓣外侧环进行。
与对照组相比，RA组显示两组的基础临床和超声心动图参数、房室瓣舒张早期（E）和晚期（A）速度、E/A比值以及肺静脉多普勒参数相似。与健康对照组相比，RA患者的左、右心室E波减速时间和等容舒张时间均增加（P<0.05）。RA患者的彩色M型血流传播速度显著降低（P<0.05）。虽然左、右心室TDI参数中的S'峰和E'峰在两组中相似，但RA组的A'峰、E'/A'和E/E'参数在RA患者中显示出统计学显著差异。
RA患者与健康个体的年龄和性别比较显示，RA患者的左、右心室TDI参数受损，这使我们得出结论，两个心室可能均受累。
Zotero 插件