Tao Jin, Xiao Ying-Lian, Chen Min-Hu, Peng Sui, Lin Jin-Kun, Xiong Li-Shou, Hu Pin-Jin
Department of Gastroenterology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Zhonghua Yi Xue Za Zhi. 2007 Feb 6;87(6):392-5.
To observe the changes of dilated intercellular space (DIS) of esophageal epithelium in different subtypes of gastroesophageal reflux disease (GERD) before and after esomeprazole treatment.
Nineteen patients with GERD, 6 with erosive esophagitis (EE), 7 with NERD with abnormal acid exposure (NERD pH+), and 6 with NERD with normal acid exposure (NERD pH-), were treated with esomeprazole 40 mg daily for two months. During endoscopy before and after treatment, six biopsy specimens were taken from the apparently normal mucosa 3 - 5 cm above the dentate line in the esophagus to undergo HE staining and histological examination and transmission electron microscopy (TEM). Fifteen normal subjects were used as controls.
Two months after the treatment 5 cases (83.33%) in the EE group, 6 cases (85.57%) in the NERD pH+ group, and 5 cases (83.33%) in the NERD pH- group showed a complete recovery of DIS and complete disappearance of the symptom of heartburn. Two of the left three patients who showed incomplete recovery of DIS still had heartburn.
A complete recovery of DIS 2 months after treatment of esomeprazole is always accompanied by resolution of heartburn symptom. No significant difference in complete recovery of DIS can be found among different GERD subgroups.
观察埃索美拉唑治疗前后不同亚型胃食管反流病（GERD）食管上皮细胞间隙增宽（DIS）的变化。
19例GERD患者，其中6例为糜烂性食管炎（EE），7例为酸暴露异常的非糜烂性反流病（NERD pH+），6例为酸暴露正常的非糜烂性反流病（NERD pH-），每日口服埃索美拉唑40 mg，疗程2个月。治疗前后行内镜检查时，于食管齿状线上方3 - 5 cm处外观正常的黏膜取6块活检标本，进行苏木精-伊红（HE）染色、组织学检查及透射电子显微镜（TEM）检查。选取15名正常受试者作为对照。
治疗2个月后，EE组5例（83.33%）、NERD pH+组6例（85.57%）、NERD pH-组5例（83.33%）的DIS完全恢复，烧心症状完全消失。其余3例DIS未完全恢复的患者中有2例仍有烧心症状。
埃索美拉唑治疗2个月后DIS完全恢复常伴有烧心症状的缓解。不同GERD亚组之间DIS的完全恢复情况无显著差异。
