Rohrmann Sabine, Nelson William G, Rifai Nader, Brown Terry R, Dobs Adrian, Kanarek Norma, Yager James D, Platz Elizabeth A
Division of Cancer Epidemiology, German Cancer Research Center, D-69120 Heidelberg, Germany.
J Clin Endocrinol Metab. 2007 Jul;92(7):2519-25. doi: 10.1210/jc.2007-0028. Epub 2007 Apr 24.
Higher testosterone in black compared with white men has been postulated to explain their higher prostate cancer incidence. Previous studies comparing hormone levels by race might have been limited by size, restricted age variation, or lack of representation of the general population.
Our objective was to compare serum testosterone, estradiol, and SHBG concentrations among non-Hispanic black, non-Hispanic white, and Mexican-American men.
PARTICIPANTS, DESIGN, AND SETTING: A total of 1413 men aged 20+ yr and who attended the morning examination session of the Third National Health and Nutrition Examination Survey (NHANES III) in 1988-1991 were included in this cross-sectional study.
Serum hormone concentrations were measured by electrochemiluminescence immunoassays.
After applying sampling weights and adjusting for age, percent body fat, alcohol, smoking, and activity, testosterone concentrations were not different between non-Hispanic blacks (n = 363; geometric mean, 5.29 ng/ml) and non-Hispanic whites (n = 674; 5.11 ng/ml; P > 0.05) but were higher in Mexican-Americans (n = 376; 5.48 ng/ml; P < 0.05). Non-Hispanic blacks (40.80 pg/ml) had a higher estradiol concentration than non-Hispanic whites (35.46 pg/ml; P < 0.01) and Mexican-Americans (34.11 pg/ml; P < 0.01). Non-Hispanic blacks (36.49 nmol/liter) had a higher SHBG concentration than non-Hispanic whites (34.91 nmol/liter; P < 0.05) and Mexican-Americans (35.04 nmol/liter; P < 0.05).
Contrary to the postulated racial difference, testosterone concentrations did not differ notably between black and white men. However, blacks had higher estradiol levels. Mexican-Americans had higher testosterone than whites but similar estradiol and SHBG concentrations. Given these findings, it may be equally if not more important to investigate estradiol as testosterone in relation to diseases with racial disparity.
据推测，黑人男性睾酮水平高于白人男性可解释其前列腺癌发病率较高的原因。以往按种族比较激素水平的研究可能受到样本量、年龄差异受限或缺乏一般人群代表性的限制。
我们的目的是比较非西班牙裔黑人、非西班牙裔白人和墨西哥裔美国男性的血清睾酮、雌二醇和性激素结合球蛋白（SHBG）浓度。
参与者、设计与研究地点：本横断面研究纳入了1988 - 1991年参加第三次全国健康与营养检查调查（NHANES III）上午检查环节的1413名20岁及以上男性。
采用电化学发光免疫分析法测定血清激素浓度。
应用抽样权重并校正年龄、体脂百分比、酒精、吸烟和活动情况后，非西班牙裔黑人（n = 363；几何均值，5.29 ng/ml）和非西班牙裔白人（n = 674；5.11 ng/ml；P > 0.05）的睾酮浓度无差异，但墨西哥裔美国人（n = 376；5.48 ng/ml；P < 0.05）的睾酮浓度较高。非西班牙裔黑人（40.80 pg/ml）的雌二醇浓度高于非西班牙裔白人（35.46 pg/ml；P < 0.01）和墨西哥裔美国人（34.11 pg/ml；P < 0.01）。非西班牙裔黑人（36.49 nmol/升）的SHBG浓度高于非西班牙裔白人（34.91 nmol/升；P < 0.05）和墨西哥裔美国人（35.04 nmol/升；P < 0.05）。
与推测的种族差异相反，黑人和白人男性的睾酮浓度无显著差异。然而，黑人的雌二醇水平较高。墨西哥裔美国人的睾酮水平高于白人，但雌二醇和SHBG浓度相似。鉴于这些发现，在研究与种族差异相关的疾病时，研究雌二醇与研究睾酮同样重要，甚至可能更重要。
