不同水平的HIV免疫控制下血清白细胞介素-7浓度与淋巴细胞减少之间的关系。

Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control.

作者信息

Fluur Caroline, Rethi Bence, Thang Pham Hong, Vivar Nancy, Mowafi Frida, Lopalco Lucia, Foppa Caterina Uberti, Karlsson Anders, Tambussi Giuseppe, Chiodi Francesca

机构信息

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

出版信息

AIDS. 2007 May 11;21(8):1048-50. doi: 10.1097/QAD.0b013e32810c8caa.

DOI:10.1097/QAD.0b013e32810c8caa

PMID:17457102

Abstract

Serum IL-7 levels correlate with T-cell depletion in HIV-infected individuals. In some patients, we observed that serum IL-7 decreases upon progression to AIDS, suggesting a role for IL-7 in T-cell maintenance in sporadic cases. Interestingly, IL-7 levels were significantly lower in stable long-term non-progressors (LTNP) than in patients who lost the LTNP status in a 3-year follow-up (P < 0.001), indicating that the serum IL-7 concentration might be a valuable marker for maintenance of the LTNP state.

摘要

血清白细胞介素-7（IL-7）水平与HIV感染个体的T细胞耗竭相关。在一些患者中，我们观察到进展为艾滋病时血清IL-7水平下降，提示在散发病例中IL-7在T细胞维持中发挥作用。有趣的是，在3年随访中，稳定的长期无进展者（LTNP）的IL-7水平显著低于失去LTNP状态的患者（P < 0.001），表明血清IL-7浓度可能是维持LTNP状态的一个有价值的标志物。