超氧化物歧化酶与顺铂的铂化反应：利用傅里叶变换离子回旋共振质谱法（FT-ICR MS）追踪氨配体
Platination of superoxide dismutase with cisplatin: tracking the ammonia ligands using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS).
作者信息
Weidt Stefan K, Mackay C Logan, Langridge-Smith Pat R R, Sadler Peter J
机构信息
School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh, UKEH9 3JJ.
出版信息
Chem Commun (Camb). 2007 May 7(17):1719-21. doi: 10.1039/b701903c. Epub 2007 Apr 5.
DOI:10.1039/b701903c
PMID:17457419
Abstract
The high mass accuracy of FT-ICR MS combined with (15)N-labelling shows that mono- and di- platinated products from the reaction of erythrocyte superoxide dismutase with the anticancer drug cisplatin in solution retain their ammine ligands, in contrast to a recent X-ray crystallographic study.
摘要
傅里叶变换离子回旋共振质谱（FT-ICR MS）的高分辨率质量分析，结合（15）N标记表明，红细胞超氧化物歧化酶与抗癌药物顺铂在溶液中反应生成的单铂和双铂产物保留了它们的氨配体，这与最近的一项X射线晶体学研究结果相反。
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