Costa Carla, Incio João, Soares Raquel
Laboratory for Molecular Cell Biology, Faculty of Medicine of the University of Porto, Al. Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.
Angiogenesis. 2007;10(3):149-66. doi: 10.1007/s10456-007-9074-0. Epub 2007 Apr 25.
Evidence has been gathered regarding the association between angiogenesis and inflammation in pathological situations. These two phenomena have long been coupled together in many chronic inflammatory disorders with distinct etiopathogenic origin, including psoriasis, rheumatoid arthritis, Crohn's disease, diabetes, and cancer. Lately, this concept has further been substantiated by the finding that several previously established non-inflammatory disorders, such as osteoarthritis and obesity, display both inflammation and angiogenesis in an exacerbated manner. In addition, the interplay between inflammatory cells, endothelial cells and fibroblasts in chronic inflammation sites, together with the fact that inflammation and angiogenesis can actually be triggered by the same molecular events, further strengthen this association. Therefore, elucidating the underlying cellular and molecular mechanisms that gather together the two processes is mandatory in order to understand their synergistic effect, and to develop new therapeutic approaches for the management of these disorders that cause a great deal of discomfort, disability, and in some cases death.
关于病理情况下血管生成与炎症之间的关联，已有相关证据。在许多具有不同病因起源的慢性炎症性疾病中，这两种现象长期以来一直相互关联，包括银屑病、类风湿性关节炎、克罗恩病、糖尿病和癌症。最近，这一概念进一步得到证实，因为有研究发现，一些先前确定的非炎症性疾病，如骨关节炎和肥胖症，也以加剧的方式表现出炎症和血管生成。此外，慢性炎症部位炎症细胞、内皮细胞和成纤维细胞之间的相互作用，以及炎症和血管生成实际上可由相同分子事件触发这一事实，进一步强化了这种关联。因此，阐明将这两个过程联系在一起的潜在细胞和分子机制，对于理解它们的协同作用以及开发针对这些引起极大不适、残疾甚至在某些情况下导致死亡的疾病的新治疗方法而言是必不可少的。
