Corvol Pierre
Médecine vasculaire, Hôpital européen Georges Pompidou, 24, rue Leblanc, 75015 Paris.
Bull Acad Natl Med. 2008 Feb;192(2):289-300; discussion 300-2.
Angiogenesis is a rapidly growing research field. Most of the important vascular growth factors have been identified in the space of a few years, as well as factors responsible for the diferentiation of arteries, veins and lymphatic vessels. The role of angiogenesis in tumor growth, exsudative retinopathies and some inflammatory diseases has been established in animal models and in the clinical setting Angiogenesis is necessary for oxygen and nutrient delivery to tissues. Hypoxia is a major determinant of angiogenesis. During adult life the vascular network is remarkably stable and there is no active angiogenesis. The endothelium is quiescent, except in some physiological circumstances such as the female reproductive cycle and muscular exercise The same molecular and cellular mechanisms as those that occur during embryonic angiogenesis are involved in physiological and pathological neoangiogenesis. Vascular endothelial growth factor (VEGF) plays a major role, and VEGF inhibition is a promising therapeutic approach to some tumoral and ocular diseases.
血管生成是一个快速发展的研究领域。在短短几年内，大多数重要的血管生长因子以及负责动脉、静脉和淋巴管分化的因子都已被确定。血管生成在肿瘤生长、渗出性视网膜病变和一些炎症性疾病中的作用已在动物模型和临床环境中得到证实。血管生成对于向组织输送氧气和营养物质是必要的。缺氧是血管生成的主要决定因素。在成年期，血管网络非常稳定，没有活跃的血管生成。除了在一些生理情况下，如女性生殖周期和体育锻炼，内皮细胞是静止的。生理和病理性新生血管生成涉及与胚胎血管生成相同的分子和细胞机制。血管内皮生长因子（VEGF）起主要作用，抑制VEGF是治疗某些肿瘤和眼部疾病的一种有前景的治疗方法。
