Schaefer Kirsten, Hansen Anders Onsberg, Maerkedahl Henrik, Rehfeld Claus, Birk Hans Okkels, Henriksen Lars Onsberg
Region Sealand, Quality and Development, Alléen, Denmark.
Pharmacoepidemiol Drug Saf. 2007 Jun;16(6):695-704. doi: 10.1002/pds.1404.
To investigate whether and how a multi-dimensional intervention including clinical guidelines on the choice of medical treatment in the primary and the secondary health care sector, and individual feedback to general practices about their own and other practices' prescription patterns in five Anatomical Therapeutic Chemical classification system (ATC)-groups was followed by changes in the practices' prescription pattern.
Prospective historical registry study and a questionnaire study of GPs' self-reported use of guidelines and feedback.
In every ATC-group the number of prescribed defined daily doses (DDDs) kept growing after the intervention, while potential savings by DDD decreased. Individual practices' changes in the prescription pattern differed by ATC-group and practices with high potential savings/DDD before the intervention showed the greatest relative reduction in potential savings/DDD. The county's average cost/DDD for the five ATC-groups declined from above the Danish average before the intervention to a level below the average cost/DDD after the intervention. In the questionnaire study (response rate: 79%), 69% of respondents had read the guidelines and 78% reported that the feedback influenced their prescription of drugs.
The observed changes in drug costs and potential savings were not due to volume effects but a combination of price effects, including generic substitution and choice of less expensive analogues, demonstrating that it is possible to change GPs' prescription patterns without interfering with patients' access to treatment or with GPs' clinical freedom.'
探讨在初级和二级卫生保健部门实施包括药物治疗选择临床指南以及针对五个解剖治疗化学分类系统(ATC)组中各诊所自身及其他诊所处方模式的个体反馈在内的多维干预措施后,诊所的处方模式是否以及如何发生变化。
前瞻性历史登记研究以及对全科医生关于指南使用和反馈的自我报告进行问卷调查研究。
在每个ATC组中,干预后规定的限定日剂量(DDD)数量持续增长,而DDD带来的潜在节省量下降。各诊所处方模式的变化因ATC组而异,干预前潜在节省量/DDD较高的诊所,其潜在节省量/DDD的相对降幅最大。五个ATC组所在县的平均成本/DDD从干预前高于丹麦平均水平降至干预后低于平均成本/DDD的水平。在问卷调查研究中(回复率:79%),69%的受访者阅读了指南,78%的受访者表示反馈影响了他们的药物处方。
观察到的药物成本变化和潜在节省并非由于量的影响,而是价格效应的综合结果,包括通用名替代和选择较便宜的类似物,这表明在不影响患者获得治疗或全科医生临床自主权的情况下,改变全科医生的处方模式是可能的。