Jie Xiu-Ling, Jin Gui-Wen, Cheng Jin-Ping, Wang Wen-Hua, Lu Jing, Qu Li-Ya
School of Environmental Science and Engineering, Shanghai Jiaotong University, Shanghai, China.
Biomed Environ Sci. 2007 Feb;20(1):84-9.
To study the oxidative stress induced by consumption of mercury-contaminated rice in rats, and to assess the possible public health risk of mercury contamination in Wanshan mining area.
Sprague Dawley rats were fed the mercury-contaminated rice produced from Wanshan area for 90 days. The antioxidant status and the free radicals in rat serum were evaluated.
High mercury accumulation in organs of rats fed the mercury-contaminated rice confirmed the server pollution of mercury in Wanshan mining area. The intensity of electron spin resonance (ESR) signal increased by 87.38% in rats fed the rice from Wanshan compared with that in the control rats fed the rice from Shanghai, suggesting that chronic dietary consumption of rice from mercury mining area could induce an aggravation of free radicals. Feeding the mercury-contaminated rice was associated with significant decreases in the antioxidant enzymatic activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and concentration of serum nitric oxide (NO), but it had no effect on serum nitric oxide synthase (NOS) activity. Feeding the mercury-contaminated rice raised the level of serum malonyldialdehyde (MDA), indicating the occurrence of oxidative stress.
The long-term dietary consumption of mercury-contaminated rice induces the aggravation of free radicals and exerts oxidative stress.
研究食用汞污染大米对大鼠造成的氧化应激，并评估万山矿区汞污染可能带来的公共卫生风险。
用万山地区产出的汞污染大米喂养斯普拉格-道利大鼠90天。评估大鼠血清中的抗氧化状态和自由基。
食用汞污染大米的大鼠器官中汞蓄积量高，证实了万山矿区汞污染严重。与喂食上海大米的对照大鼠相比，喂食万山大米的大鼠电子自旋共振（ESR）信号强度增加了87.38%，这表明长期食用汞矿区大米会导致自由基增加。喂食汞污染大米会使超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的抗氧化酶活性以及血清一氧化氮（NO）浓度显著降低，但对血清一氧化氮合酶（NOS）活性没有影响。喂食汞污染大米会提高血清丙二醛（MDA）水平，表明发生了氧化应激。
长期食用汞污染大米会导致自由基增加并产生氧化应激。
