Alexiou Zoi, Mouktaroudi Maria, Koratzanis George, Papadopoulos Antonios, Kavatha Dimitra, Kanellakopoulou Kyriaki, Giamarellou Helen, Giamarellos-Bourboulis Evangelos J
4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece.
Int J Antimicrob Agents. 2007 Jul;30(1):40-3. doi: 10.1016/j.ijantimicag.2007.02.017. Epub 2007 Apr 24.
In an attempt to define the most important driver responsible for recurrence of cystitis in women, 181 records were retrospectively analysed among 1010 consecutive references in a tertiary centre for lower urinary tract infections (UTIs). All 181 women had more than three episodes of cystitis per year; 129 were under continuous prophylaxis and 52 were under postcoital prophylaxis. Analysis revealed that the most important factor affecting successful outcome of chemoprophylaxis was the compliance of patients (odds ratio 0.074; P<0.0001). Among women treated for >or=6 months, the most effective regimen was nitrofurantoin, with a success rate of 96.8% compared with 82.8% for trimethoprim/sulphamethoxazole and 72.3% for norfloxacin (P=0.046 between agents). Failure of chemoprophylaxis was observed in 51 women in total; in 26 of them resistance to the administered agent had developed. Results of this retrospective study revealed that the most important driver leading to failure of prophylaxis for recurrent lower UTIs was the lack of compliance of women with their medication. Nitrofurantoin was the most potent among the administered agents.
为了确定导致女性膀胱炎复发的最重要因素，我们对一家三级中心下尿路感染（UTIs）连续1010份参考文献中的181份记录进行了回顾性分析。所有181名女性每年膀胱炎发作超过3次；129人接受持续预防，52人接受性交后预防。分析表明，影响化学预防成功结果的最重要因素是患者的依从性（比值比0.074；P<0.0001）。在接受治疗≥6个月的女性中，最有效的方案是呋喃妥因，成功率为96.8%，而甲氧苄啶/磺胺甲恶唑为82.8%，诺氟沙星为72.3%（各药物之间P=0.046）。总共51名女性化学预防失败；其中26人对所用药物产生了耐药性。这项回顾性研究的结果表明，导致复发性下尿路感染预防失败的最重要因素是女性服药依从性差。在所使用的药物中，呋喃妥因效力最强。
