DeBey Brad M, Jacob Binod, Oehme Fred W, Imerman Paula
Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, 1800 Denison Avenue, Manhattan, KS 66506, USA.
J Vet Diagn Invest. 2007 May;19(3):305-8. doi: 10.1177/104063870701900315.
Fourteen cattle on a Kansas pasture died from ingestion of a wood preservative compound containing sodium fluoride and copper naphthenate. Clinical signs included depression, anorexia, ataxia, diarrhea, and recumbency. Grossly visible lesions included perirenal edema, pale kidneys, and forestomach ulceration. All 3 cows that had postmortem evaluations had extensive renal cortical tubular necrosis. Tissue concentrations of fluoride were slightly elevated above expected background levels, while copper tissue concentrations were not elevated. The findings indicated that the sodium fluoride caused renal tubular necrosis leading to renal failure. Copper naphthenate may have contributed to abomasal ulceration; however, tissue copper concentrations indicated that copper from the formulation was not appreciably absorbed from the gastrointestinal tract.
堪萨斯州一处牧场的14头牛因摄入一种含有氟化钠和环烷酸铜的木材防腐剂化合物而死亡。临床症状包括抑郁、厌食、共济失调、腹泻和卧地不起。肉眼可见的病变包括肾周水肿、肾脏苍白和前胃溃疡。所有3头进行了尸检的奶牛都有广泛的肾皮质肾小管坏死。氟化物的组织浓度略高于预期的背景水平，而铜的组织浓度没有升高。研究结果表明，氟化钠导致肾小管坏死，进而导致肾衰竭。环烷酸铜可能导致了皱胃溃疡；然而，组织铜浓度表明，制剂中的铜并未从胃肠道大量吸收。
