Zutt Markus, Haas Ellen, Kruger Ullrich, Distler Meike, Neumann Christine
Department of Dermatology and Venereology, Georg-August-Universitat Gottingen, Gottingen, Germany.
Dermatology. 2007;214(4):319-24. doi: 10.1159/000100882.
Leg ulcers caused by vasculitis, small vessel occlusion or other rare conditions often prove to be very difficult to treat. Despite polypragmatic, systemic and localized therapy, many of these wounds are progressive and characterized by severe pain.
We here portray the cases of 5 patients with ulcers resistant to systemic therapy for the underlying disease, who were treated successfully using vacuum-assisted closure (VAC) for wound management. We present the advantages and disadvantages of this method, as well as illustrating the essential and known therapeutic principles.
Our experience shows VAC to be an excellent and effective alternative in the treatment of therapy-resistant chronic wounds caused by vasculopathy (small vessel occlusion or vasculitis). We did not observe any pathergy or proinflammatory effects caused by VAC.
由血管炎、小血管闭塞或其他罕见病症引起的腿部溃疡往往极难治疗。尽管采用了多种综合、全身及局部治疗方法，但许多此类伤口仍不断进展，并伴有剧痛。
我们在此描述了5例因基础疾病而对全身治疗耐药的溃疡患者的病例，他们通过负压封闭引流（VAC）进行伤口处理而获得成功治疗。我们介绍了该方法的优缺点，并阐述了基本的和已知的治疗原则。
我们的经验表明，VAC是治疗由血管病变（小血管闭塞或血管炎）引起的难治性慢性伤口的一种出色且有效的替代方法。我们未观察到VAC引起的任何同形反应或促炎效应。
