D'Erasmo E, Acca M, Celi F S, Minisola S, Spagna G, Aliberti G, Mazzuoli G
IV Patologia Medica, Università La Sapienza, Rome, Italy.
Tumori. 1991 Aug 31;77(4):311-4. doi: 10.1177/030089169107700403.
We evaluated the incidence of hypo- versus hypercalcemia and hypo- versus hyperphosphatemia in a survey of 158 patients with malignancy; 55/158 had bone metastases. When serum calcium levels were corrected for albuminemia, the incidence of hypo- and hypercalcemia was respectively 10.8% and 10.1%. Hypophosphatemia was found in 29.7% patients, hyperphosphatemia in 2.5%. The incidence was slightly different in presence of bone metastases. Hypocalcemia and hypophosphatemia prevailed in osteoblastic metastases and hypercalcemia in osteolytic metastases. The incidence of hypocalcemia and hypophosphatemia in malignancy was therefore surprisingly high, even apart from the presence of bone metastases. Both hypo- and hypercalcemia were associated with elevated serum alkaline phosphatase levels. Moreover, a calcium-phosphorus product reduction was observed in osteoblastic metastases, suggesting a condition of secondary hyperparathyroidism.
我们在一项对158例恶性肿瘤患者的调查中评估了低钙血症与高钙血症以及低磷血症与高磷血症的发生率；其中55/158例有骨转移。校正白蛋白血症后的血清钙水平显示，低钙血症和高钙血症的发生率分别为10.8%和10.1%。29.7%的患者存在低磷血症，2.5%的患者存在高磷血症。在有骨转移的情况下，发生率略有不同。成骨细胞转移中以低钙血症和低磷血症为主，溶骨细胞转移中以高钙血症为主。因此，即使不考虑骨转移的存在，恶性肿瘤中低钙血症和低磷血症的发生率也出奇地高。低钙血症和高钙血症均与血清碱性磷酸酶水平升高有关。此外，在成骨细胞转移中观察到钙磷乘积降低，提示继发性甲状旁腺功能亢进状态。
