Moshfeghi Darius M, Blumenkranz Mark S
Department of Ophthalmology, Stanford University School of Medicine, Stanford, California, USA.
Retina. 2007 Mar;27(3):269-75. doi: 10.1097/IAE.0b013e31802e3e9b.
Complement factor H (CFH) has been implicated in the predisposition to advanced forms of age-related macular degeneration (AMD). The purpose of this review is to highlight recent discoveries implicating single nucleotide polymorphisms on 1q32, 6p21, and 10q26 in the risk for development of AMD. In addition, the central role of CFH in the complement cascade and its role in the inflammatory hypothesis for AMD are reviewed.
补体因子H（CFH）与晚期年龄相关性黄斑变性（AMD）的易感性有关。本综述的目的是强调最近的发现，即1q32、6p21和10q26上的单核苷酸多态性与AMD发生风险有关。此外，还综述了CFH在补体级联反应中的核心作用及其在AMD炎症假说中的作用。
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