Tsypin L E, Prokop'ev G G, Lazarev V V, Shchukin V V, Popova T G, Kochkin V S, Lin'kova T V, Chusov K P
Anesteziol Reanimatol. 2007 Jan-Feb(1):4-7.
The investigation evaluated the effect of various volatile anesthetics on cerebral blood volume and oxygen status in sick children at the stage of anesthesia induction. Ninety-two children were distributed into 3 groups: Groups 1 (n = 36) and 2 (n = 24) underwent stepwise induction with halothane and enflurane, respectively. Group 3 (n = 32) had vital capacity rapid inhalation induction with sevoflurane. Cerebral oximetry (NIRS method) was used to measure the content of hydroxyhemoglobin, deoxyhemoglobin, the total level of hemoglobin and to assess regional cerebral tissue saturation (rSO2). Halothane was ascertained to increase cerebral blood volume by 20.5% whereas enflurane and sevoflurane increased it only by 8.8 and 9.0%, respectively. In all cases, the value of rSO2 remained comparatively high, by exceeding the baseline level by 3-5%.
该研究评估了在麻醉诱导阶段各种挥发性麻醉剂对患病儿童脑血容量和氧状态的影响。92名儿童被分为3组：第1组（n = 36）和第2组（n = 24）分别采用氟烷和恩氟烷进行逐步诱导。第3组（n = 32）采用七氟烷进行肺活量快速吸入诱导。采用脑血氧饱和度测定法（近红外光谱法）测量羟基血红蛋白、脱氧血红蛋白的含量、血红蛋白总水平，并评估局部脑组织饱和度（rSO2）。已确定氟烷可使脑血容量增加20.5%，而恩氟烷和七氟烷分别仅使其增加8.8%和9.0%。在所有情况下，rSO2值均保持相对较高，比基线水平高出3 - 5%。
