睾丸的发育和下降与隐睾症的关系。
Development and descent of the testis in relation to cryptorchidism.
作者信息
Virtanen Helena E, Cortes Dina, Rajpert-De Meyts Ewa, Ritzén E Martin, Nordenskjöld Agneta, Skakkebaek Niels E, Toppari Jorma
机构信息
Department of Physiology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland.
出版信息
Acta Paediatr. 2007 May;96(5):622-7. doi: 10.1111/j.1651-2227.2007.00244.x.
UNLABELLED
The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development.
CONCLUSION
Since testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis.
未标注
睾丸下降分为两个阶段。动物研究表明，睾丸经腹下降取决于胰岛素样激素3（INSL3）。雄激素在动物和人类睾丸腹股沟阴囊下降过程中起重要作用。一般来说，隐睾症的病因尚不清楚，其病因可能是多因素的。隐睾组织学变化显示发育紊乱。
结论
由于睾丸下降受睾丸源性激素调节，隐睾症可能反映睾丸的功能缺陷。
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