病毒载体疫苗可产生抗疟疾的记忆T细胞。
Viral vector vaccines make memory T cells against malaria.
作者信息
Reyes-Sandoval Arturo, Harty John T, Todryk Stephen M
机构信息
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
出版信息
Immunology. 2007 Jun;121(2):158-65. doi: 10.1111/j.1365-2567.2006.02552.x.
Abstract
Vaccines that comprise attenuated viral vectors encoding antigens from target pathogens generate potent T-cell responses. One such pathogen is malaria, and in particular the liver stage of its life cycle. Immunogenicity and efficacy studies in animals and humans have revealed the generation of memory T cells of both the central and effector phenotypes, depending on the viral vectors used in the malaria vaccination regime (viral species and serotype, combination and sequence for prime-boost) and suggest a divergence in their protective role. Being able to influence the memory T-cell make-up in a rational manner may allow us to develop more efficacious vaccines.
摘要
包含编码来自目标病原体抗原的减毒病毒载体的疫苗可产生强大的T细胞反应。疟疾就是这样一种病原体，尤其是其生命周期中的肝脏阶段。在动物和人类中进行的免疫原性和疗效研究表明，根据疟疾疫苗接种方案中使用的病毒载体（病毒种类和血清型、初免-加强的组合和顺序），会产生中枢和效应表型的记忆T细胞，并表明它们在保护作用上存在差异。能够以合理的方式影响记忆T细胞的组成可能会使我们开发出更有效的疫苗。
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