对温血动物转录调控区域中G4 DNA基序进行富集的广泛筛选。
Extensive selection for the enrichment of G4 DNA motifs in transcriptional regulatory regions of warm blooded animals.
作者信息
Zhao Yiqiang, Du Zhuo, Li Ning
机构信息
State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, 10094, China.
出版信息
FEBS Lett. 2007 May 15;581(10):1951-6. doi: 10.1016/j.febslet.2007.04.017. Epub 2007 Apr 18.
A comprehensive analysis of potential G4 DNA motifs (G4Ms) in genomic regions flanking transcription start sites (TSS) was performed across 13 animal species. We found that G4Ms are significantly enriched in the transcriptional regulatory regions (TRRs) of warm-blooded animals. Further analysis of human genes in different temporal groups reveals that the enrichment is not specific to genes found only in warm-blooded species but instead exist in a wide range of genes. Our findings therefore suggest that the high prevalence of G4Ms in TRRs is extensively selected in warm-blooded animals, supporting the hypothesis that G4Ms are involved in the regulation of gene transcription.
我们对13种动物转录起始位点（TSS）侧翼基因组区域中的潜在G4 DNA基序（G4M）进行了全面分析。我们发现，G4M在温血动物的转录调控区域（TRR）中显著富集。对不同时间组的人类基因进行的进一步分析表明，这种富集并非仅存在于温血动物特有的基因中，而是广泛存在于各种基因中。因此，我们的研究结果表明，TRR中G4M的高丰度在温血动物中经过广泛选择，支持了G4M参与基因转录调控的假说。
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