非编码DNA的进化：有多少是垃圾，有多少具有功能？

The evolution of noncoding DNA: how much junk, how much func?

作者信息

Castillo-Davis Cristian I

机构信息

Department of Statistics, Harvard University, Cambridge, MA 02138, USA.

出版信息

Trends Genet. 2005 Oct;21(10):533-6. doi: 10.1016/j.tig.2005.08.001.

DOI:10.1016/j.tig.2005.08.001

PMID:16098630

Abstract

Comparative sequence analysis on a genomic scale has opened the door for the systematic analysis of cis-acting regulatory DNA. It is now possible to begin to answer basic questions such as, how much meaningful noncoding sequence is in the genome? How strong is natural selection on functional noncoding sequences in different species? Two recent articles have capitalized on the comparative genomic approach in an attempt to answer these questions with surprising results.

摘要

基因组规模的比较序列分析为顺式作用调控DNA的系统分析打开了大门。现在有可能开始回答一些基本问题，比如，基因组中有多少有意义的非编码序列？不同物种中对功能性非编码序列的自然选择有多强？最近的两篇文章利用了比较基因组学方法来试图回答这些问题，结果令人惊讶。