Seki Kazutaka, Ueno Masaharu, Kobayashi Shū
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Org Biomol Chem. 2007 May 7;5(9):1347-50. doi: 10.1039/b701466j. Epub 2007 Apr 10.
A storable, powdered chiral zirconium catalyst for asymmetric aldol and hetero Diels-Alder reactions has been developed. The catalyst has the same activity as that prepared in situ even after being stored for 3 months. Moreover, this chiral Zr catalyst worked efficiently not only for asymmetric aldol reactions but also for asymmetric hetero Diels-Alder reactions affording the corresponding addition products with high enantioselectivities.
一种用于不对称羟醛反应和杂环狄尔斯-阿尔德反应的可储存的粉末状手性锆催化剂已被开发出来。即使储存3个月后，该催化剂仍具有与原位制备的催化剂相同的活性。此外，这种手性锆催化剂不仅在不对称羟醛反应中表现高效，而且在不对称杂环狄尔斯-阿尔德反应中也能高效工作，以高对映选择性得到相应的加成产物。
