与母亲低出生体重相关的早产风险。

Risk of preterm delivery in relation to maternal low birth weight.

作者信息

De Barna, Lin Stephanie, Lohsoonthorn Vitool, Williams Michelle A

机构信息

Department of Epidemiology, Multidisciplinary International Research Training Program, University of Washington School of Public Health and Community Medicine, Seattle, WA 98195, USA.

出版信息

Acta Obstet Gynecol Scand. 2007;86(5):565-71. doi: 10.1080/00016340701223127.

DOI:10.1080/00016340701223127

PMID:17464585

Abstract

OBJECTIVE

We examined the relationship between maternal low birth weight and preterm delivery risk.

METHODS

Information concerning maternal birth weight was collected during in-person interviews. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI). Preterm delivery cases were studied in aggregate, in subgroups (spontaneous preterm labor, preterm premature rupture of membranes, medically induced preterm delivery, moderate preterm delivery [gestational age at delivery 34-36 weeks], and early preterm delivery [gestational age at delivery<34 weeks]).

RESULTS

After adjusting for confounders, women weighing<2,500 g at birth had a 1.54-fold increased risk of preterm delivery versus women weighing=2,500 g (95% CI 0.97-2.44). Maternal low birth weight was associated with a 2-fold increased risk of spontaneous preterm delivery (95% CI 1.03-3.89), but weakly associated with preterm premature rupture of membranes (OR=1.44; 95% CI 0.67-3.09) and medically induced preterm delivery (OR=1.10; 95% CI 0.43-2.82). Maternal low birth weight was more strongly associated with early preterm delivery (OR=1.94) than with moderate preterm delivery (OR=1.46). Women weighing<2,500 g at birth and who became obese (pre-pregnancy body mass index, =30 kg/m2) before pregnancy had a 3.65-fold increased risk of preterm delivery (95% CI 1.33-10.02) versus women weighing=2,500 g at birth and who were not obese prior to pregnancy (<30 kg/m2).

CONCLUSIONS

Results confirm earlier findings linking maternal low birth weight with future risk of preterm delivery.

摘要

目的

我们研究了母亲低出生体重与早产风险之间的关系。

方法

在面对面访谈中收集有关母亲出生体重的信息。采用逻辑回归来估计比值比（OR）和95%置信区间（95%CI）。对早产病例进行总体研究，并按亚组进行分析（自发性早产、胎膜早破早产、医源性早产、中度早产[分娩孕周为34 - 36周]和早期早产[分娩孕周<34周]）。

结果

在对混杂因素进行调整后，出生时体重<2500g的女性早产风险是出生体重≥2500g女性的1.54倍（95%CI 0.97 - 2.44）。母亲低出生体重与自发性早产风险增加2倍相关（95%CI 1.03 - 3.89），但与胎膜早破早产（OR = 1.44；95%CI 0.67 - 3.09）和医源性早产（OR = 1.10；95%CI 0.43 - 2.82）的相关性较弱。母亲低出生体重与早期早产（OR = 1.94）的相关性比与中度早产（OR = 1.46）更强。出生时体重<2500g且孕前肥胖（孕前体重指数≥30kg/m²）的女性早产风险是出生体重≥2500g且孕前不肥胖（<30kg/m²）女性的3.65倍（95%CI 1.33 - 10.02）。