Intapad Suttira, Alexander Barbara T
Department of Physiology and Biophysics and the Women's Health Research Center, University of Mississippi Medical Center, Jackson, MS, 39216.
Curr Cardiovasc Risk Rep. 2013 Jun 1;7(3):183-189. doi: 10.1007/s12170-013-0303-3.
Pregnancy complications such as preeclampsia and diabetes affect approximately 5 to 10 % of all pregnancies and compromise maternal and fetal health during gestation. Complications during pregnancy may also contribute to the development of hypertension and future cardiovascular risk in the mother. Moreover, fetal exposure to hypertension and diabetes during pregnancy can program hypertension and cardiovascular disease in the offspring. Transgenerational transmission of programmed cardiovascular risk highlights the importance of understanding the mechanisms that link complications during pregnancy with later hypertension in her offspring and subsequent generations. However, experimental studies are needed to investigate the cause and effect of increased blood pressure in the mother following a complicated pregnancy and provide insight into the development of preventative measures that may improve the long-term cardiovascular health of women and their offspring.
诸如先兆子痫和糖尿病等妊娠并发症影响着约5%至10%的所有妊娠，并在妊娠期损害母婴健康。孕期并发症还可能导致母亲患高血压及未来心血管疾病风险增加。此外，胎儿在孕期暴露于高血压和糖尿病环境可使后代出现高血压和心血管疾病。程序化心血管疾病风险的跨代传递凸显了了解将孕期并发症与后代及后续几代人日后患高血压联系起来的机制的重要性。然而，需要进行实验研究来调查复杂妊娠后母亲血压升高的因果关系，并深入了解可能改善女性及其后代长期心血管健康的预防措施的制定。
